Preheat the oven to 400 degrees Fahrenheit.
Spray a large, rimmed baking sheet with cooking spray or brush with olive oil.
In a large bowl, combine the seasoned panko, parmesan cheese, sea salt, black pepper and garlic powder until evenly mixed.
Add egg, Worcestershire sauce, and whole milk to mixture. Mix until evenly combined.
Add beef and mix with your hands or a stand mixer until thoroughly combined. Stop once combined and do not overmix.
Use a cookie scoop to portion out even amounts of the meatball mixture onto the baking sheet.
Use your hands to gently shape the meatballs to nice round balls and place evenly apart on the baking sheet.
Bake in the upper half of the oven for 20-40 minutes depending on the size of your meatballs.
Cook meatballs until they are brown and have reached an internal temperature of 165 degrees Fahrenheit.
